Affordable Access

deepdyve-link
Publisher Website

Lung cell exposure to secondary photochemical aerosols generated from OH oxidation of cyclic siloxanes.

Authors
  • King, Benjamin M1
  • Janechek, Nathan J1
  • Bryngelson, Nathan1
  • Adamcakova-Dodd, Andrea2
  • Lersch, Traci3
  • Bunker, Kristin3
  • Casuccio, Gary3
  • Thorne, Peter S2
  • Stanier, Charles O4
  • Fiegel, Jennifer5
  • 1 Department of Chemical and Biochemical Engineering, The University of Iowa, 4133 Seamans Center for the Engineering Arts and Sciences, Iowa City, IA, 52242, USA.
  • 2 Department of Occupational and Environmental Health, The University of Iowa, 145 N. Riverside Dr., Iowa City, IA, 52242, USA.
  • 3 RJ Lee Group, 350 Hochberg Road, Monroeville, PA, 15146, USA.
  • 4 Department of Chemical and Biochemical Engineering, The University of Iowa, 4133 Seamans Center for the Engineering Arts and Sciences, Iowa City, IA, 52242, USA. Electronic address: [email protected]
  • 5 Department of Chemical and Biochemical Engineering, The University of Iowa, 4133 Seamans Center for the Engineering Arts and Sciences, Iowa City, IA, 52242, USA. Electronic address: [email protected]
Type
Published Article
Journal
Chemosphere
Publication Date
Feb 01, 2020
Volume
241
Pages
125126–125126
Identifiers
DOI: 10.1016/j.chemosphere.2019.125126
PMID: 31683444
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To study the fate of cyclic volatile methyl siloxanes (cVMS) undergoing photooxidation in the environment and to assess the acute toxicity of inhaled secondary aerosols from cVMS, we used an oxidative flow reactor (OFR) to produce aerosols from oxidation of decamethylcyclopentasiloxane (D5). The aerosols produced from this process were characterized for size, shape, and chemical composition. We found that the OFR produced aerosols composed of silicon and oxygen, arranged in chain agglomerates, with primary particles of approximately 31 nm in diameter. Lung cells were exposed to the secondary organosilicon aerosols at estimated doses of 54-116 ng/cm2 using a Vitrocell air-liquid interface system, and organic gases and ozone exposure was minimized through a series of denuders. Siloxane aerosols were not found to be highly toxic. Copyright © 2019 Elsevier Ltd. All rights reserved.

Report this publication

Statistics

Seen <100 times