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Lung cancer mimicking systemic lupus erythematosus: case-based review.

Authors
  • Liu, Jia1
  • Hu, Song1
  • Niu, Min2
  • Wang, Hua3
  • Wang, Yan3
  • Tang, Ning3
  • Liu, Bin4
  • 1 Department of Geriatrics, The Affiliated Hospital of Qingdao University, No. 16 of Jiangsu Road, Qingdao, 266003, Shandong, China. , (China)
  • 2 Department of Pharmacy, The Affiliated Hospital of Qingdao University, No. 16 of Jiangsu Road, Qingdao, 266003, Shandong, China. , (China)
  • 3 Department of Rheumatology, The Affiliated Hospital of Qingdao University, No. 16 of Jiangsu Road, Qingdao, 266003, Shandong, China. , (China)
  • 4 Department of Rheumatology, The Affiliated Hospital of Qingdao University, No. 16 of Jiangsu Road, Qingdao, 266003, Shandong, China. [email protected] , (China)
Type
Published Article
Journal
Rheumatology International
Publisher
Springer-Verlag
Publication Date
May 01, 2021
Volume
41
Issue
5
Pages
981–986
Identifiers
DOI: 10.1007/s00296-019-04356-y
PMID: 31612248
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The aim of this study was to analyze the clinical features of lupus-like lung adenocarcinoma, thus improving both the recognition of lupus mimickers and diagnosis accuracy. We collected three cases of lung adenocarcinoma in which the clinical characteristics and laboratory profiles imitated systemic lupus erythematosus (SLE) in our hospital, and also we had a literature review using search engine. There are few reports of lung adenocarcinoma for which the clinical and laboratory profiles meet the criteria for SLE diagnosis. Follow-up and pathological biopsy are beneficial for the differential diagnosis. Few lung adenocarcinoma cases resemble SLE. Gene pleiotropy and immune dysregulation might be contributing factors. Lung adenocarcinoma should be considered in the differential diagnosis of SLE. Follow-up and pathological biopsy should be improved to enable early detection of lung adenocarcinoma-associated lupus-like conditions.

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