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Lunelle monthly contraceptive injection (medroxyprogesterone acetate and estradiol cypionate injectable suspension): steady-state pharmacokinetics of MPA and E2 in surgically sterile women.

Authors
  • Rahimy, M H
  • Ryan, K K
  • Hopkins, N K
Type
Published Article
Journal
Contraception
Publisher
Elsevier
Publication Date
Oct 01, 1999
Volume
60
Issue
4
Pages
209–214
Identifiers
PMID: 10640167
Source
Medline
Keywords
License
Unknown

Abstract

This paper characterized the pharmacokinetics and pharmacodynamics of medroxyprogesterone acetate (MPA) and estradiol cypionate (E2C) in 14 healthy, surgically sterile women. These women ranged in age from 28 to 43.4 years, in body weight from 47.6 to 68.9 kg, and in height from 150 to 175 cm. The results of this study demonstrate that steady-state conditions are achieved after the first injection of MPA/E2C; no further MPA or E2C accumulation occurs beyond the first injection. Moreover, the E2 peak observed after injection of MPA/E2C is similar to the nontreated preovulatory E2 range and returns to baseline levels by approximately 14 days after insertion.

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