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Luminescent cell-penetrating pentadecanuclear lanthanide clusters.

Authors
  • Thielemann, Dominique T
  • Wagner, Anna T
  • Rösch, Esther
  • Kölmel, Dominik K
  • Heck, Joachim G
  • Rudat, Birgit
  • Neumaier, Marco
  • Feldmann, Claus
  • Schepers, Ute
  • Bräse, Stefan
  • Roesky, Peter W
Type
Published Article
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society
Publication Date
May 22, 2013
Volume
135
Issue
20
Pages
7454–7457
Identifiers
DOI: 10.1021/ja403539t
PMID: 23650953
Source
Medline
License
Unknown

Abstract

A novel pentadecanuclear lanthanide hydroxy cluster [{Ln15(μ3-OH)20(PepCO2)10(DBM)10Cl}Cl4] (Ln = Eu (1), Tb (2)) featuring the first example with peptoids as supporting ligands was prepared and fully characterized. The solid-state structures of 1 and 2 were established via single-crystal X-ray crystallography. ESI-MS experiments revealed the retention of the cluster core in solution. Although OH groups are present, 1 showed intense red fluorescence with 11(1)% absolute quantum yield, whereas the emission intensity and the quantum yield of 2 were significantly weaker. In vitro investigations on 1 and 2 with HeLa tumor cells revealed an accumulation of the clusters in the endosomal-lyosomal system, as confirmed by confocal microscopy in the TRLLM mode. The cytotoxicity of 1 and 2 toward the HeLa cells is moderate.

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