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Lumen-positive chloride transport potential in the early distal tubule of Triturus kidney: its absolute dependence on the presence of Na+ and K+ in the luminal fluid.

Authors
  • Hoshi, T
  • Kuramochi, G
  • Yoshitomi, K
Type
Published Article
Journal
The Japanese journal of physiology
Publication Date
Jan 01, 1983
Volume
33
Issue
5
Pages
855–861
Identifiers
PMID: 6321832
Source
Medline
License
Unknown

Abstract

Microperfusion experiments with Na+-free and/or K+-free solutions revealed that the generation of Cl- -dependent lumen-positive transtubular potentials of the early distal tubule of Triturus kidney was absolutely dependent on the presence of both Na+ and K+ in the lumen. Increases in luminal Na+ or K+ concentration increased the luminal positivity in a saturable manner, and the half saturation concentration was found to be about 1 mM for both cations. The results strongly suggest that Cl- is cotransported with Na+ and K+ across the luminal membrane.

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