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L-selectin regulates human neutrophil transendothelial migration

Authors
  • Rahman, Izajur1
  • Collado Sánchez, Aida2,
  • Davies, Jessica1
  • Rzeniewicz, Karolina1
  • Abukscem, Sarah1
  • Joachim, Justin1
  • Hoskins Green, Hannah L.1
  • Killock, David1
  • Sanz, Maria Jesus2,
  • Charras, Guillaume3
  • Parsons, Maddy4
  • Ivetic, Aleksandar1
  • 1 James Black Centre, School of Cardiovascular Medicine and Sciences, 125 Coldharbour Lane, London SE5 9NU
  • 2 University of Valencia, Department of Pharmacology and Faculty of Medicine and Odontology, Av. Blasco Ibáñez 15, 46010 Valencia , (Spain)
  • 3 UK, London Centre for Nanotechnology, London WC1H 0AH
  • 4 King's College London, Randall Centre for Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, London SE1 1UL
Type
Published Article
Journal
Journal of Cell Science
Publisher
The Company of Biologists
Publication Date
Feb 08, 2021
Volume
134
Issue
3
Identifiers
DOI: 10.1242/jcs.250340
PMID: 33408247
PMCID: PMC7888707
Source
PubMed Central
Keywords
License
Green

Abstract

Highlighted Article: Neutrophil L-selectin co-clusters with PECAM-1 in cis during transendothelial migration (TEM). Clustering neutrophil PECAM-1 activates p38 MAPK and JNK to regulate L-selectin shedding, which in turn expedites TEM.

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