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LSD1 sustains pancreatic cancer growth via maintaining HIF1α-dependent glycolytic process

Authors
  • Qin, Yi
  • Zhu, Wenwei
  • Xu, Wenyan
  • Zhang, Bo
  • Shi, Si
  • Ji, Shunrong
  • Liu, Jiang
  • Long, Jiang
  • Liu, Chen
  • Liu, Liang
  • Xu, Jin
  • Yu, Xianjun1, 2, 3, 4, 5, 6, 5
  • 1 Department of Pancreatic and Hepatobiliary Surgery
  • 2 Fudan University Shanghai Cancer Center
  • 3 Department of Oncology
  • 4 Shanghai Medical College
  • 5 Fudan University
  • 6 Pancreatic Cancer Institute
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Jan 01, 2014
Accepted Date
Feb 13, 2014
Identifiers
DOI: 10.1016/j.canlet.2014.02.013
Source
Elsevier
Keywords
License
Unknown

Abstract

The histone demethylase LSD1 (lysine specific demethylase 1) plays an important role in the epigenetic regulation of gene transcription. Our study investigated the role of LSD1 in pancreatic cancer and demonstrated that LSD1 was significantly up-regulated in pancreatic cancer patient tissue samples, and elevated LSD1 protein levels positively correlated with overall survival of pancreatic cancer patients. Using in vitro and in vivo models, we demonstrated that knock-down of LSD1 repressed proliferation and tumorigenicity of pancreatic cancer cells. Mechanistically, our study demonstrated that LSD1 synergized with HIF1α (hypoxia inducible factor-1α) in maintaining glycolytic process, which fueled pancreatic cancer uncontrolled proliferation.

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