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Low-Resistance, Concentric-Gated Pediatric Artificial Lung for End-Stage Lung Failure.

Authors
  • Thompson, Alex J1
  • Buchan, Skylar1
  • Carr, Benjamin1
  • Poling, Clinton1
  • Hayes, McKenzie1
  • Fernando, Uditha Piyumindri1
  • Kaesler, Andreas2
  • Schlanstein, Peter2
  • Hesselmann, Felix2
  • Arens, Jutta2
  • Potkay, Joseph A1
  • Rojas-PeÑa, Alvaro1
  • Bartlett, Robert H1
  • Hirschl, Ronald B1
  • 1 From the Extracorporeal Life Support Laboratory, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
  • 2 Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Aachen, Germany. , (Germany)
Type
Published Article
Journal
ASAIO journal (American Society for Artificial Internal Organs : 1992)
Publication Date
Apr 01, 2020
Volume
66
Issue
4
Pages
423–432
Identifiers
DOI: 10.1097/MAT.0000000000001018
PMID: 31192843
Source
Medline
Language
English
License
Unknown

Abstract

Children with end-stage lung failure awaiting lung transplant would benefit from improvements in artificial lung technology allowing for wearable pulmonary support as a bridge-to-transplant therapy. In this work, we designed, fabricated, and tested the Pediatric MLung-a dual-inlet hollow fiber artificial lung based on concentric gating, which has a rated flow of 1 L/min, and a pressure drop of 25 mm Hg at rated flow. This device and future iterations of the current design are designed to relieve pulmonary arterial hypertension, provide pulmonary support, reduce ventilator-associated injury, and allow for more effective therapy of patients with end-stage lung disease, including bridge-to-transplant treatment.

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