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Low-Grade Inflammation Is Not Present in Former Obese Males but Adipose Tissue Macrophage Infiltration Persists

Authors
  • ara, ignacio
  • auerbach, pernille
  • larsen, steen
  • mata, esmeralda
  • stallknecht, bente
  • ploug, thorkil
  • prats, clara
  • helge, jørn w.
Publication Date
May 14, 2020
Identifiers
DOI: 10.3390/biomedicines8050123
OAI: oai:mdpi.com:/2227-9059/8/5/123/
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

Macrophage infiltration in two subcutaneous adipose tissue depots and systemic low-grade inflammation were studied in post-obese (PO), obese (O), and control (C) subjects. Young males were recruited into PO: (n = 10, weight-loss avg. 26%, BMI: 26.6 &plusmn / 0.7, mean &plusmn / SEM kg/m2), O: (n = 10, BMI: 33.8 &plusmn / 1.0kg/m2) and C: (n = 10, BMI: 26.6 &plusmn / 0.6 kg/m2). PO and C were matched by BMI. Blood and abdominal and gluteal subcutaneous adipose tissue were obtained in the overnight fasted state. Plasma concentrations of IL-6 and CRP were higher (p &lt / 0.05) in O than in PO and C, TNF-&alpha / was higher (p &lt / 0.05) only in O compared to PO and IL-18 was similar between groups. The number of CD68+ macrophages was higher (p &lt / 0.05) in the gluteal than the abdominal depot, and higher (p &lt / 0.05) in O and PO compared to C in both depots. The content of CD163+ macrophages was similar between depots but was higher (p &lt / 0.05) in PO compared to C and O in the gluteal depot. In post obese men with a long-term sustained weight loss, systemic low-grade inflammation was similar to non-obese controls despite a higher subcutaneous adipose tissue CD68+ macrophage content. Interestingly, the anti-inflammatory CD163+ macrophage adipose tissue content was consistently higher in post obese than obese and controls.

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