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Lower functional capacity is associated with higher cardiovascular risk in Brazilian patients with intermittent claudication.

  • Gengo e Silva, Rita de Cassia1
  • de Melo, Vanessa Ferreira Amorim2
  • Wolosker, Nelson3
  • Consolim-Colombo, Fernanda Marciano4
  • 1 School of Nursing, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: [email protected] , (Brazil)
  • 2 Heart Institute (InCor), Medical School, University of Sao Paulo, Sao Paulo, Brazil. , (Brazil)
  • 3 Claudication Unit, Vascular and Endovascular Surgery Department, Medical School, University of Sao Paulo, Sao Paulo, Brazil. , (Brazil)
  • 4 Laboratory of Human Clinical Investigation of Hypertension Unit, Heart Institute (InCor), Medical School, University of Sao Paulo, Sao Paulo, Brazil. , (Brazil)
Published Article
Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing
Publication Date
March 2015
DOI: 10.1016/j.jvn.2014.08.001
PMID: 25700734


The purpose of this study was to examine the association between cardiovascular risk estimated by the Framingham Risk Score and functional capacity in patients with peripheral artery disease using a 6-minute walk test. Fifty-six participants with intermittent claudication were recruited. The Framingham Risk Score was calculated and used to split the participants into two groups: Group A (mild and moderate risk) and group B (severe risk). The ankle-brachial index (ABI) was calculated for each leg using a handheld Doppler probe. Walking ability was verified by a 6-minute walk test. Descriptive statistics were used to describe the sample's demographic and clinical characteristics. To compare clinical data between the two groups, a t test or Mann-Whitney test was used as appropriate according to the type of variable being analyzed. The Pearson coefficient was used to verify the association between cardiovascular risk and functional capacity. Group A had 19 participants (60.5 ± 6.3 years; 36.8% male) and group B had 37 participants (63.4 ± 8.7 years; 73% male). No differences were observed when comparing the ABI between both groups. The total distances covered by the men in group A were shorter compared with those of group B (331.4 + 51.5 vs 257.9 + 84.0; P = .02). The cardiovascular risk score was negative and was significantly correlated with total distances for men (r = -0.53; P = .001) and with pain-free distances for women (r = -0.46; P = .03). Functional capacity, evaluated through a 6-minute walk test, seems to be associated with 10-year total mortality risk.

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