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Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E epsilon 4 allele.

Authors
  • Reed, T
  • Carmelli, D
  • Swan, G E
  • Breitner, J C
  • Welsh, K A
  • Jarvik, G P
  • Deeb, S
  • Auwerx, J
Type
Published Article
Journal
Archives of Neurology
Publisher
American Medical Association
Publication Date
Dec 01, 1994
Volume
51
Issue
12
Pages
1189–1192
Identifiers
PMID: 7986172
Source
Medline
License
Unknown

Abstract

The apoE epsilon 4 allele may be associated with decreased cognitive function in discordant twin pairs. Our results suggest that epsilon 4 may represent a potential marker for accelerated cognitive aging and such individuals may be at greater risk for development of late-onset Alzheimer dementia or multi-infarct dementia.

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