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Low-Dose Tirofiban Improves Functional Outcome in Acute Ischemic Stroke Patients Treated With Endovascular Thrombectomy.

Authors
  • Zhao, Wenbo1
  • Che, Ruiwen1
  • Shang, Shuyi1
  • Wu, Chuanjie1
  • Li, Chuanhui1
  • Wu, Longfei1
  • Chen, Jian1
  • Duan, Jiangang1
  • Song, Haiqing1
  • Zhang, Hongqi1
  • Ling, Feng1
  • Wang, Yuping1
  • Liebeskind, David1
  • Feng, Wuwei1
  • Ji, Xunming2
  • 1 From the Department of Neurology (W.Z., R.C., S.S., C.W., L.W., J.D., H.S., Y.W.) and Department of Neurosurgery (C.L., J.C., H.Z., F.L., X.J.), Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA (D.L.); and Department of Neurology, Medical University of South Carolina, Charleston (W.F.). , (China)
  • 2 From the Department of Neurology (W.Z., R.C., S.S., C.W., L.W., J.D., H.S., Y.W.) and Department of Neurosurgery (C.L., J.C., H.Z., F.L., X.J.), Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA (D.L.); and Department of Neurology, Medical University of South Carolina, Charleston (W.F.). [email protected] , (China)
Type
Published Article
Journal
Stroke
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Dec 01, 2017
Volume
48
Issue
12
Pages
3289–3294
Identifiers
DOI: 10.1161/STROKEAHA.117.019193
PMID: 29127270
Source
Medline
Keywords
License
Unknown

Abstract

In patients with AIS undergoing ET, tirofiban is not associated with higher sICH, it seems to lead to lower odds of deaths and better odds of long-term functional independence. Further investigations are needed to determine the efficacy of tirofiban in preventing early reocclusion, the underlying mechanisms, and its optimal treatment protocol.

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