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Low-calcium diet in mice leads to reduced gut colonization by Enterococcus faecium.

Authors
  • Top, Janetta1
  • Hendrickx, Antoni P A1
  • van Ampting, Marleen T J2
  • van Limpt, Kees2
  • Knol, Jan2
  • van de Kamer, Denise1
  • Braat, Johanna C1
  • Viveen, Marco1
  • Rogers, Malbert R1
  • Kemperman, Hans3
  • Willems, Rob J L1
  • Paganelli, Fernanda L1
  • 1 Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands. , (Netherlands)
  • 2 Danone Nutricia Research, Utrecht, The Netherlands. , (Netherlands)
  • 3 Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands. , (Netherlands)
Type
Published Article
Journal
MicrobiologyOpen
Publisher
Wiley (John Wiley & Sons)
Publication Date
Sep 30, 2019
Identifiers
DOI: 10.1002/mbo3.936
PMID: 31568701
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The aim of this study was to determine whether dietary intervention influenced luminal Ca2+ levels and Enterococcus faecium gut colonization in mice. For this purpose, mice fed semi-synthetic food AIN93 were compared to mice fed AIN93-low calcium (LC). Administration of AIN93-LC resulted in lower luminal Ca2+ levels independent of the presence of E. faecium. Furthermore, E. faecium gut colonization was reduced in mice fed AIN93-LC based on culture, and which was in concordance with a reduction of Enterococcaceae in microbiota analysis. In conclusion, diet intervention might be a strategy for controlling gut colonization of E. faecium, an important opportunistic nosocomial pathogen. © 2019 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd.

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