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Low serum ferroxidase I activity is associated with mortality in heart failure and related to both peroxynitrite-induced cysteine oxidation and tyrosine nitration of ceruloplasmin.

Authors
Type
Published Article
Journal
Circulation Research
1524-4571
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Volume
114
Issue
11
Pages
1723–1732
Identifiers
DOI: 10.1161/CIRCRESAHA.114.302849
PMID: 24687133
Source
Medline
Keywords
License
Unknown

Abstract

Reduced activity of serum FeOxI is associated with ceruloplasmin nitration and reduced survival in patients with HF. Both ceruloplasmin tyrosine nitration and cysteine thiol oxidation may be operant in vivo in peroxynitrite-induced FeOxI activity inhibition.

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