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Low Prolactin and High 20-α-Hydroxysteroid Dehydrogenase Levels Contribute to Lower Progesterone Levels in HIV-Infected Pregnant Women Exposed to Protease Inhibitor-Based Combination Antiretroviral Therapy.

Authors
  • Papp, Eszter1
  • Balogun, Kayode1
  • Banko, Nicole1
  • Mohammadi, Hakimeh1
  • Loutfy, Mona2
  • Yudin, Mark H3
  • Shah, Rajiv4
  • MacGillivray, Jay4
  • Murphy, Kellie E5
  • Walmsley, Sharon L6
  • Silverman, Michael7
  • Serghides, Lena8
  • 1 Toronto General Research Institute, University Health Network.
  • 2 Women's College Research Institute, Women's College Hospital Department of Medicine.
  • 3 Department of Medicine St. Michael's Hospital.
  • 4 St. Michael's Hospital.
  • 5 Department of Medicine Mount Sinai Hospital, Toronto.
  • 6 Toronto General Research Institute, University Health Network Department of Medicine.
  • 7 University of Western Ontario, London, Canada.
  • 8 Toronto General Research Institute, University Health Network Women's College Research Institute, Women's College Hospital Department of Immunology, University of Toronto.
Type
Published Article
Journal
The Journal of Infectious Diseases
Publisher
Oxford University Press
Publication Date
May 15, 2016
Volume
213
Issue
10
Pages
1532–1540
Identifiers
DOI: 10.1093/infdis/jiw004
PMID: 26740274
Source
Medline
Keywords
License
Unknown

Abstract

Our data suggest that the decrease in progesterone levels observed in HIV-infected pregnant women exposed to PI-based cART is caused, at least in part, by an increase in placental expression of 20α-HSD, which may be due to lower prolactin levels observed in these women.

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