Low Prolactin and High 20-α-Hydroxysteroid Dehydrogenase Levels Contribute to Lower Progesterone Levels in HIV-Infected Pregnant Women Exposed to Protease Inhibitor-Based Combination Antiretroviral Therapy.
Toronto General Research Institute, University Health Network.
Women's College Research Institute, Women's College Hospital Department of Medicine.
Department of Medicine St. Michael's Hospital.
St. Michael's Hospital.
Department of Medicine Mount Sinai Hospital, Toronto.
Toronto General Research Institute, University Health Network Department of Medicine.
University of Western Ontario, London, Canada.
Toronto General Research Institute, University Health Network Women's College Research Institute, Women's College Hospital Department of Immunology, University of Toronto.
- Published Article
The Journal of Infectious Diseases
Oxford University Press
- Publication Date
May 15, 2016
Our data suggest that the decrease in progesterone levels observed in HIV-infected pregnant women exposed to PI-based cART is caused, at least in part, by an increase in placental expression of 20α-HSD, which may be due to lower prolactin levels observed in these women.
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This record was last updated on 07/07/2017 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/26740274