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A low-Mr factor isolated from Escherichia coli inhibits eukaryotic in vitro protein synthesis.

Authors
  • Skelly, S M
  • Clark, V L
Type
Published Article
Journal
FEBS Letters
Publisher
Wiley (John Wiley & Sons)
Publication Date
Oct 03, 1983
Volume
162
Issue
1
Pages
16–20
Identifiers
PMID: 6352334
Source
Medline
License
Unknown

Abstract

The effect of a low-Mr factor, partially purified from E. coli B, was investigated in E. coli, reticulocyte, and wheat germ lysate in vitro protein synthesis systems. Equal concentrations of factor were needed to inhibit protein synthesis in the eukaryotic system as compared to the prokaryotic system. Experiments suggested that the factor inhibits the initiation step in the eukaryotic systems.

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