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Low mortality of hospitalised patients with COVID-19 in a tertiary Danish hospital setting

Authors
  • Madsen, Lone Wulff1, 2, 3
  • Lindvig, Susan Olaf1
  • Rasmussen, Line Dahlerup1
  • Knudtzen, Fredrikke Christie1, 3, 4
  • Laursen, Christian B.3, 5
  • Øvrehus, Anne1, 3
  • Nielsen, Stig Lønberg1
  • Johansen, Isik Somuncu1, 3
  • 1 Department of Infectious Diseases, Odense University Hospital, Odense, Denmark
  • 2 OPEN, Open Patient data Explorative Network, Odense University Hospital, University of Southern Denmark, Odense, Denmark
  • 3 Department of Clinical Research, University of Southern Denmark, Odense, Denmark
  • 4 Clinical Center of Emerging and Vector-borne Infections, Odense University Hospital, Denmark
  • 5 Department of Respiratory Medicine, Odense University Hospital, Denmark
Type
Published Article
Journal
International Journal of Infectious Diseases
Publisher
The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
Publication Date
Oct 12, 2020
Volume
102
Pages
212–219
Identifiers
DOI: 10.1016/j.ijid.2020.10.018
PMID: 33059095
PMCID: PMC7550098
Source
PubMed Central
Keywords
License
Unknown

Abstract

Objectives We aimed to describe clinical characteristics and outcomes of admitted COVID-19 patients in a Danish hospital setting where an early active government intervention was taken. Methods Prospective cohort study including all admitted patients to the COVID-19 unit at Odense University Hospital from March 10 to April 21, 2020. Patients were assessed by a multidisciplinary team at admission. Outcome parameters were development of acute respiratory distress syndrome (ARDS), intensive care unit (ICU) admission, death and admission time. Results We included 83 patients (median age 62 years, 62.7% male). At hospitalization, 31.3% needed oxygen supplementation and the median National Early Warning Score was four. Median admission time was 7 days (Interquartile ranges (IQR) 3-12). In total, ARDS was diagnosed in 33.7% (28/83) of the patients corresponding to an incidence rate of 7.1 per 100 person days (95% CI: 4.1-10.2). Overall 13 patients (15.7%) were transferred to the ICU of whom 11 (84.6%) received corticosteroids.. No patients died while admitted to the ICU. Four patients (4.8%) died during admission. Conclusion Despite similar patient characteristics compared to those reported by others, we found a low overall mortality of < 5%.

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