Affordable Access

Low molecular weight proteins in children with renal disease.

Authors
  • Tomlinson, P A
Type
Published Article
Journal
Pediatric nephrology (Berlin, Germany)
Publication Date
Nov 01, 1992
Volume
6
Issue
6
Pages
565–571
Identifiers
PMID: 1282825
Source
Medline
License
Unknown

Abstract

Low molecular weight proteins are of interest in children because their increased urinary excretion is a sign of renal tubular disease and their increased plasma concentration is inversely related to glomerular filtration rate. These proteins include beta 2-microglobulin (B2M), retinol-binding protein (RBP), alpha 1-microglobulin (A1M) and lysozyme. B2M is unstable in acid urine, in contrast to RBP and A1M which are more stable. Any increase in the urinary excretion of B2M or RBP is highly specific for tubular disease, whereas increased excretion of A1M may be seen with glomerular proteinuria. Areas of clinical application include tubular and glomerular diseases, detection of drug toxicity, reflux nephropathy, birth asphyxia and insulin-dependent diabetes mellitus. Methods of sample collection and analysis of these proteins are discussed.

Report this publication

Statistics

Seen <100 times