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Low-loading asymmetric organocatalysis.

Authors
  • Giacalone, Francesco1
  • Gruttadauria, Michelangelo
  • Agrigento, Paola
  • Noto, Renato
  • 1 Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari (STEMBIO) Sez. Chimica Organica E. Paternò, Università di Palermo, Viale delle Scienze, Ed. 17, 90128, Palermo, Italy. , (Italy)
Type
Published Article
Journal
Chemical Society reviews
Publication Date
Mar 21, 2012
Volume
41
Issue
6
Pages
2406–2447
Identifiers
DOI: 10.1039/c1cs15206h
PMID: 22167174
Source
Medline
License
Unknown

Abstract

Asymmetric organocatalysis is now recognized as the third pillar of asymmetric synthesis. Recent years have witnessed increasing interest towards the use of highly active and stereoselective organocatalysts. This critical review documents the advances in the development of chiral organocatalysts which are systematically used in ≤3 mol% loading in all the sub-areas of the field, namely aminocatalysis, Brønsted acids and bases, Lewis acids and bases, hydrogen bond-mediated catalysis, phase transfer and N-heterocyclic carbene catalyses (194 references).

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