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A Low Level of Darunavir Resistance–Associated Mutation Emergence in Patients With Virological Failure During Long-term Use of Darunavir in People With HIV. The ANRS CO3 Aquitaine Cohort

Authors
  • Chaussade, Hélène1
  • Tumiotto, Camille2
  • Le Marec, Fabien3
  • Leleux, Olivier3
  • Lefèvre, Lucile4
  • Lazaro, Estibaliz1
  • Lafon, Marie-Edith2
  • Nyamankolly, Elsa5
  • Duffau, Pierre1
  • Neau, Didier5
  • Bellecave, Pantxika2
  • Bonnet, Fabrice1, 3
  • 1 CHU Bordeaux, Services de Médecine Interne et Maladies Infectieuses, France , (France)
  • 2 CHU Bordeaux, Virology Laboratory, France , (France)
  • 3 Univ. Bordeaux, ISPED, Inserm, Bordeaux Population Health Research Center, Team MORPH3Eus, France , (France)
  • 4 JANSSEN France, Issy-les-Moulineaux, France , (France)
  • 5 CHU Bordeaux, Service des Maladies Infectieuses et Tropicales, France , (France)
Type
Published Article
Journal
Open Forum Infectious Diseases
Publisher
Oxford University Press
Publication Date
Nov 19, 2020
Volume
7
Issue
12
Identifiers
DOI: 10.1093/ofid/ofaa567
PMID: 33409332
PMCID: PMC7772944
Source
PubMed Central
Keywords
Disciplines
  • Editor's Choice
License
Unknown

Abstract

A low level of darunavir resistance-associated mutation emergence in patients with virological failure during long term use of boosted darunavir. Confirmation of the robustness of this protease inhibitor in the ANRS CO3 Aquitaine cohort in a real life setting.

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