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Low expression of nuclear Toll-like receptor 4 in laryngeal papillomas transforming into squamous cell carcinoma.

Authors
  • Ilmarinen, Taru1
  • Hagström, Jaana2
  • Haglund, Caj3
  • Auvinen, Eeva4
  • Leivo, Ilmo5
  • Pitkäranta, Anne6
  • Aaltonen, Leena-Maija6
  • 1 Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland [email protected] , (Finland)
  • 2 Department of Pathology, Haartman Institute, Helsinki University Hospital, University of Helsinki, Helsinki, Finland Helsinki University Hospital Laboratory, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. , (Finland)
  • 3 Department of Pathology, Haartman Institute, Helsinki University Hospital, University of Helsinki, Helsinki, Finland Department of Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. , (Finland)
  • 4 Helsinki University Hospital Laboratory, Helsinki University Hospital, University of Helsinki, Helsinki, Finland Department of Virology, Haartman Institute, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. , (Finland)
  • 5 Department of Pathology, Turku University Hospital, University of Turku, Turku, Finland. , (Finland)
  • 6 Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. , (Finland)
Type
Published Article
Journal
Otolaryngology
Publisher
SAGE Publications
Publication Date
Nov 01, 2014
Volume
151
Issue
5
Pages
785–790
Identifiers
DOI: 10.1177/0194599814549730
PMID: 25205638
Source
Medline
Keywords
License
Unknown

Abstract

The expression of TLR4 may serve as a predictive marker of malignant transformation in LPs. High immunoexpression of cytoplasmic TLR4 in LSCC was associated with a more aggressive disease.

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