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Low doses of bisphenol A can impair postnatal testicular development directly, without affecting hormonal or oxidative stress levels.

Authors
  • Ogo, Fernanda M1
  • Siervo, Glaucia E M L1
  • Gonçalves, Géssica D1
  • Cecchini, Rubens2
  • Guarnier, Flavia A2
  • Anselmo-Franci, Janete Ap3
  • Fernandes, Glaura S A1
  • 1 Department of General Biology, Biological Sciences Center, State University of Londrina, Rodovia Celso Garcia Cid, PR 445 - Km 380, Campus Universitário, 86057-970, Londrina, Paraná, Brazil. , (Brazil)
  • 2 Department of General Pathology, Biological Sciences Center, State University of Londrina, Rodovia Celso Garcia Cid, PR 445 - Km 380, Campus Universitário, 86057-970, Londrina, Paraná, Brazil. , (Brazil)
  • 3 Department of Morphology, Physiology and Basic Pathology, School of Dentistry of Ribeirão Preto, University of São Paulo, FORP, Av. do Café - S/N, 14040-904, Ribeirão Preto, São Paulo, Brazil. , (Brazil)
Type
Published Article
Journal
Reproduction, fertility, and development
Publication Date
Oct 01, 2017
Volume
29
Issue
11
Pages
2245–2254
Identifiers
DOI: 10.1071/RD16432
PMID: 28384430
Source
Medline
License
Unknown

Abstract

Bisphenol A (BPA) is considered a potent endocrine disruptor, causing changes in the endocrine system due to its oestrogenic activity. Male individuals may be susceptible to endocrine, morphological and physiological alterations during testicular postnatal development. The aim of the present study was to evaluate whether exposure to BPA during the peripubertal period can damage testicular development. To this end, male Wistar rats were treated with BPA via gavage at doses of 20 or 200µgkg-1 on Postnatal Days (PND) 36-66. The control group was treated with Oil+DMSO under the same conditions. On PND 67, rats were killed. The blood was collected for hormonal analysis, the testis for sperm count, oxidative stress, histopathological and immunohistochemical analyses for ki-67 and sperm of the vas deferens for morphological analysis. Both doses of BPA resulted in abnormal sperm morphology and seminiferous tubules, with the highest dose increasing the height of the germinal epithelium and reducing the number of spermatozoa at Stages IX-XIII of spermatogenesis. In conclusion, both doses of BPA administered during the peripubertal period impaired testicular development without any effects on hormone levels (luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone levels) or oxidative stress.

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