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Low Bone Mineral Density Is Not Associated with Subclinical Atherosclerosis: A Population-Based Study in Rural China

Authors
  • Jiang, Yanfeng
  • Fan, Zehan
  • Wang, Yingzhe
  • Suo, Chen
  • Cui, Mei
  • Yuan, Ziyu
  • Tian, Weizhong
  • Fan, Min
  • Zhang, Dekun
  • Wang, Xiaofeng
  • Jin, Li
  • Ye, Weimin
  • Li, Shuyuan
  • Chen, Xingdong
Type
Published Article
Journal
Cardiology
Publisher
S. Karger AG
Publication Date
Nov 13, 2018
Volume
141
Issue
2
Pages
78–87
Identifiers
DOI: 10.1159/000493166
PMID: 30423564
Source
Karger
Keywords
License
Green
External links

Abstract

Objectives: Loss of bone mass may affect the progression of atherosclerosis. We investigated the relationship between low bone mineral density (BMD) and subclinical atherosclerosis in rural China. Methods: In total, 333 men and 421 postmenopausal women aged 55–65 years were enrolled. BMD was measured in the lumbar spine, femoral neck, and total hip using dual-energy X-ray absorptiometry. Subclinical atherosclerosis was defined as increased carotid artery intima-media thickness (CIMT ≥0.9 mm), the presence of carotid plaques, high brachial-ankle pulse wave velocity (baPWV ≥1,400 cm/s), and low ankle-brachial index (ABI ≤1). Binary logistic regression analyses were used to estimate the association between low BMD and subclinical atherosclerosis. Results: There was no significant difference in BMD between the normal group and the subclinical atherosclerosis group. After full adjustment for the relevant covariates, a boundary significant association was found between low BMD in the femoral neck and baPWV in postmenopausal women (odds ratio = 1.77, p = 0.049). After full adjustment, neither BMD nor low BMD were significantly associated with subclinical atherosclerosis in men or postmenopausal women. Conclusions: Low BMD is not associated with subclinical atherosclerosis in Chinese individuals aged 55–65 years resident in rural China.

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