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Low body mass index has minimal impact on plasma levels of cytokines and chemokines in tuberculous lymphadenitis.

Authors
  • Kathamuthu, Gokul Raj1, 2
  • Sridhar, Rathinam3
  • Baskaran, Dhanaraj2
  • Babu, Subash1, 4
  • 1 National Institutes of Health-NIRT-International Center for Excellence in Research, Chennai, India. , (India)
  • 2 National Institute for Research in Tuberculosis, Chennai, India. , (India)
  • 3 Government Stanley Medical Hospital, Chennai, India. , (India)
  • 4 Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Type
Published Article
Journal
Journal of clinical tuberculosis and other mycobacterial diseases
Publication Date
Aug 01, 2020
Volume
20
Pages
100163–100163
Identifiers
DOI: 10.1016/j.jctube.2020.100163
PMID: 32420460
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Malnutrition, due to low body mass index (LBMI), is considered to be one of the key risk factors for tuberculosis (TB) development. The link between pro and anti-inflammatory cytokines and BMI has been studied in active pulmonary TB. However, the association of BMI with cytokines and chemokines in TB lymphadenitis (TBL) has not been examined. Hence, we wanted to examine the plasma levels of different cytokines and chemokines in TBL individuals with LBMI, normal BMI (NBMI) and high BMI (HBMI). LBMI with TBL disease is associated with enhanced systemic levels of type 1 (tumor necrosis factor alpha [TNFα], interleukin-2 [IL-2]) and type 2 (IL-4, IL-13) cytokines in comparison with NBMI and/or HBMI. However, other pro-inflammatory (IFNγ, IL-1β, IL-17A, IL-6, IL-7, IL-12, G-CSF, and GM-CSF) and anti-inflammatory (IL-5 and IL-10) cytokines were not significantly different among the TBL individuals with different BMI status. Likewise, no significant differences were observed in the CC (CCL-1, CCL-2/MCP-1, CCL3/MIP1α, CCL4/MIP-1β, CCL11/eotaxin) and CXC (CXCL-1/GRO-⍺, CXCL2/GRO-β, CXCL9/MIG, CXCL10/IP-10, CXCL11/ITAC 1) chemokine profile among the TBL individuals with different BMI. Hence, our data implies that TBL individuals with LBMI are characterized by minimal effects on plasma cytokines and chemokines in TBL. © 2020 The Authors. Published by Elsevier Ltd.

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