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Low-avidity anti-HPA-1a alloantibodies are capable of antigen-positive platelet destruction in the NOD/SCID mouse model of alloimmune thrombocytopenia.

Authors
  • Bakchoul, Tamam
  • Kubiak, Sebastian
  • Krautwurst, Annika
  • Roderfeld, Monika
  • Siebert, Hans C
  • Bein, Gregor
  • Sachs, Ulrich J
  • Santoso, Sentot
Type
Published Article
Journal
Transfusion
Publication Date
Nov 01, 2011
Volume
51
Issue
11
Pages
2455–2461
Identifiers
DOI: 10.1111/j.1537-2995.2011.03171.x
PMID: 21564107
Source
Medline
License
Unknown

Abstract

Low-avidity HPA-1a antibodies are present in a significant number of NAIT cases and, although they can escape detection by standard serology, they harbor the capability of PLT destruction in vivo.

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