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LOTUS-domain proteins - developmental effectors from a molecular perspective

Authors
  • Kubíková, Jana1
  • Reinig, Rebecca1
  • Salgania, Harpreet Kaur1
  • Jeske, Mandy1
  • 1 Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, D-69120 , (Germany)
Type
Published Article
Journal
Biological Chemistry
Publisher
Walter de Gruyter GmbH
Publication Date
Nov 04, 2020
Volume
402
Issue
1
Pages
7–23
Identifiers
DOI: 10.1515/hsz-2020-0270
Source
De Gruyter
Keywords
License
Green

Abstract

The LOTUS domain (also known as OST-HTH) is a highly conserved protein domain found in a variety of bacteria and eukaryotes. In animals, the LOTUS domain is present in the proteins Oskar, TDRD5/Tejas, TDRD7/TRAP/Tapas, and MARF1/Limkain B1, all of which play essential roles in animal development, in particular during oogenesis and/or spermatogenesis. This review summarizes the diverse biological as well as molecular functions of LOTUS-domain proteins and discusses their roles as helicase effectors, post-transcriptional regulators, and critical cofactors of piRNA-mediated transcript silencing.

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