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Loss of VLDL receptor activates retinal vascular endothelial cells and promotes angiogenesis.

Authors
  • Jiang, Aihua
  • Hu, Wenzheng
  • Meng, Hongdi
  • Gao, Hua
  • Qiao, Xiaoxi
Type
Published Article
Journal
Investigative Ophthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
Feb 01, 2009
Volume
50
Issue
2
Pages
844–850
Identifiers
DOI: 10.1167/iovs.08-2447
PMID: 18936153
Source
Medline
License
Unknown

Abstract

VLDLR is a potent endogenous inhibitor that negatively regulates the angiogenic properties of RVECs. Loss of VLDLR activates RVECs and significantly enhances angiogenesis in vivo and in vitro.

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