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Is loss of sense of smell a diagnostic marker in COVID-19: A systematic review and meta-analysis.

  • Rocke, John1
  • Hopkins, Claire2
  • Philpott, Carl3, 4
  • Kumar, Nirmal5
  • 1 ENT Department, Royal Albert Edward Infirmary, Wigan, UK.
  • 2 Rhinology, Guy's Hospital London, London, UK.
  • 3 The Norfolk Smell & Taste Clinic, The Norfolk & Waveney ENT Service, Norwich Medical School, University of East Anglia, Norwich, UK.
  • 4 Fifth Sense, Oxfordshire, UK.
  • 5 Edge Hill University Medical School, WWL Teaching Hospital NHS Foundation Trust, Wigan, UK.
Published Article
Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
Publication Date
Nov 01, 2020
DOI: 10.1111/coa.13620
PMID: 32741085


To systematically review the currently available evidence investigating the association between olfactory dysfunction (OD) and the novel coronavirus (COVID-19). To analyse the prevalence of OD in patients who have tested positive on polymerase chain reaction (PCR) for COVID-19. To perform a meta-analysis of patients presenting with olfactory dysfunction, during the pandemic, and to investigate the positive predictive value for a COVID-19-positive result in this population. To assess whether olfactory dysfunction could be used as a diagnostic marker for COVID-19 positivity and aid public health approaches in tackling the current outbreak. We systematically searched MedLine (PubMed), Embase, Health Management Information Consortium (HMIC), Medrxiv, the Cochrane Library, the Cochrane COVID-19 Study Register, NIHR Dissemination centre, Clinical Evidence, National Health Service Evidence and the National Institute of Clinical Excellence to identify the current published evidence which associates coronaviridae or similar RNA viruses with anosmia. The initial search identified 157 articles. A total of 145 papers were excluded following application of our exclusion criteria. The 12 remaining articles that presented evidence on the association between COVID-19 and olfactory dysfunction were critically analysed. Olfactory dysfunction has been shown to be the strongest predictor of COVID-19 positivity when compared to other symptoms in logistic regression analysis. In patients who had tested positive for COVID-19, there was a prevalence of 62% of OD. In populations of patients who are currently reporting OD, there is a positive predictive value of 61% for a positive COVID-19 result. Our review has shown that there is already significant evidence which demonstrates an association between OD and the novel coronavirus-COVID-19. It is unclear if this finding is unique to this coronavirus as individual viral phenotypes rarely present in such concentrated large numbers. We have demonstrated that OD is comparatively more predictive for COVID-19 positivity compared to other associated symptoms. We recommend that people who develop OD during the pandemic should be self-isolate and this guidance should be adopted internationally to prevent transmission. © 2020 John Wiley & Sons Ltd.

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