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Loss of Selenov predisposes mice to extra fat accumulation and attenuated energy expenditure

Authors
  • Chen, Ling-Li1, 2, 3
  • Huang, Jia-Qiang1, 2
  • Wu, Yuan-Yuan1
  • Chen, Liang-Bing1, 4
  • Li, Shu-Ping1
  • Zhang, Xu1
  • Wu, Sen5
  • Ren, Fa-Zheng1, 2
  • Lei, Xin-Gen6
  • 1 Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing, 100083, China
  • 2 Key Laboratory of Precision Nutrition and Food Quality, Ministry of Education, Department of Nutrition and Health, China Agricultural University, Beijing, 100083, China
  • 3 College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, Jiangxi, 330045, China
  • 4 Life Science and Agriculture Department, Zhoukou Normal University, Zhoukou, Henan, 466001, China
  • 5 State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China
  • 6 Department of Animal Science, Cornell University, Ithaca, NY, 14853, USA
Type
Published Article
Journal
Redox Biology
Publisher
Elsevier
Publication Date
Jun 17, 2021
Volume
45
Identifiers
DOI: 10.1016/j.redox.2021.102048
PMID: 34167027
PMCID: PMC8227834
Source
PubMed Central
Keywords
Disciplines
  • Research Paper
License
Unknown

Abstract

• SELENOV knockout elevated body weight and fat mass accumulation in mice. • SELENOV knockout stimulated lipogenesis and inhibited lipolysis in adipose tissue. • SELENOV knockout attenuated thermogenesis, respiration, and body temperature. • SELENOV and O -GlcNAc transferase (OGT) depicted a protein-protein interaction. • SELENOV knockout lowered OGT protein, activity, and function in adipose tissue.

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