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Loss of consciousness reduces the stability of brain hubs and the heterogeneity of brain dynamics

Authors
  • López-González, Ane1
  • Panda, Rajanikant2, 3
  • Ponce-Alvarez, Adrián1
  • Zamora-López, Gorka1
  • Escrichs, Anira1
  • Martial, Charlotte2, 3
  • Thibaut, Aurore2, 3
  • Gosseries, Olivia2, 3
  • Kringelbach, Morten L.4, 5, 6
  • Annen, Jitka2, 3
  • Laureys, Steven2, 3
  • Deco, Gustavo1, 7
  • 1 Universitat Pompeu Fabra,
  • 2 University of Liège,
  • 3 University Hospital of Liège,
  • 4 University of Oxford,
  • 5 Aarhus University,
  • 6 University of Minho,
  • 7 Institució Catalana de la Recerca i Estudis Avançats (ICREA),
Type
Published Article
Journal
Communications Biology
Publisher
Nature Publishing Group UK
Publication Date
Sep 06, 2021
Volume
4
Identifiers
DOI: 10.1038/s42003-021-02537-9
PMID: 34489535
PMCID: PMC8421429
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

López-González et al study the fMRI brain dynamics and their underlying mechanism from patients that suffered brain injuries leading to a disorder of consciousness as well as from healthy subjects undergoing propofol-induced sedation. They show that pathological and pharmacological low-level states of consciousness display disrupted synchronization patterns, higher constraint to the anatomy and a loss of heterogeneity and stability in the structural hubs compared to conscious states.

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