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Loss of AvrSr50 by somatic exchange in stem rust leads to virulence for Sr50 resistance in wheat.

Authors
  • Chen, Jiapeng1, 2, 3
  • Upadhyaya, Narayana M2
  • Ortiz, Diana2
  • Sperschneider, Jana4
  • Li, Feng5
  • Bouton, Clement6
  • Breen, Susan2
  • Dong, Chongmei1
  • Xu, Bo2
  • Zhang, Xiaoxiao2
  • Mago, Rohit2
  • Newell, Kim2
  • Xia, Xiaodi2
  • Bernoux, Maud2
  • Taylor, Jennifer M2
  • Steffenson, Brian5
  • Jin, Yue5, 7
  • Zhang, Peng1
  • Kanyuka, Kostya6
  • Figueroa, Melania5
  • And 3 more
  • 1 Plant Breeding Institute, School of Life and Environmental Sciences, University of Sydney, Cobbitty, NSW, Australia. , (Australia)
  • 2 Commonwealth Scientific and Industrial Research Organisation, Agriculture and Food, Canberra, ACT, Australia. , (Australia)
  • 3 Judith and David Coffey Life Lab, Charles Perkins Centre, University of Sydney.
  • 4 Centre for Environment and Life Sciences, Commonwealth Scientific and Industrial Research Organisation, Agriculture and Food, Perth, WA, Australia. , (Australia)
  • 5 Department of Plant Pathology and The Stakman-Borlaug Center for Sustainable Plant Health, University of Minnesota, St. Paul, MN, USA.
  • 6 Biointeractions and Crop Protection, Rothamsted Research, Harpenden, AL5 2JQ, UK.
  • 7 United States Department of Agriculture-Agricultural Research Service (USDA-ARS), Cereal Disease Laboratory, St. Paul, MN, USA. , (United States)
Type
Published Article
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
Dec 22, 2017
Volume
358
Issue
6370
Pages
1607–1610
Identifiers
DOI: 10.1126/science.aao4810
PMID: 29269475
Source
Medline
License
Unknown

Abstract

Race-specific resistance genes protect the global wheat crop from stem rust disease caused by Puccinia graminis f. sp. tritici (Pgt) but are often overcome owing to evolution of new virulent races of the pathogen. To understand virulence evolution in Pgt, we identified the protein ligand (AvrSr50) recognized by the Sr50 resistance protein. A spontaneous mutant of Pgt virulent to Sr50 contained a 2.5 mega-base pair loss-of-heterozygosity event. A haustorial secreted protein from this region triggers Sr50-dependent defense responses in planta and interacts directly with the Sr50 protein. Virulence alleles of AvrSr50 have arisen through DNA insertion and sequence divergence, and our data provide molecular evidence that in addition to sexual recombination, somatic exchange can play a role in the emergence of new virulence traits in Pgt.

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