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Loss of angiotensin-converting enzyme 2 exacerbates myocardial injury via activation of the CTGF-fractalkine signaling pathway.

Authors
  • Song, Bei
  • Zhang, Zhen-Zhou
  • Zhong, Jiu-Chang
  • Yu, Xi-Yong
  • Oudit, Gavin Y
  • Jin, Hai-Yan
  • Lu, Lin
  • Xu, Ying-Le
  • Kassiri, Zamaneh
  • Shen, Wei-Feng
  • Gao, Ping-Jin
  • Zhu, Ding-Liang
Type
Published Article
Journal
Circulation journal : official journal of the Japanese Circulation Society
Publication Date
Jan 01, 2013
Volume
77
Issue
12
Pages
2997–3006
Identifiers
PMID: 24161906
Source
Medline
License
Unknown

Abstract

Loss of ACE2 exacerbates AngII-mediated inflammation, myocardial injury and dysfunction in ACE2-deficient hearts via activation of the CTGF-FKN-ERK and MMP signaling. ACE2 gene may represent a potential candidate to prevent and treat myocardial injury and heart diseases.

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