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A long-term survivor of recurrent esophagogastric junction adenocarcinoma treated with multidisciplinary therapy: a case report

Authors
  • Tanaka, Takako1
  • Arigami, Takaaki1
  • Uenosono, Yoshikazu1
  • Yanagita, Shigehiro1
  • Matsushita, Daisuke1
  • Okubo, Keishi1
  • Kijima, Takashi1
  • Uchikado, Yasuto1
  • Kita, Yoshiaki1
  • Mori, Shinichiro1
  • Sasaki, Ken1
  • Omoto, Itaru1
  • Kurahara, Hiroshi1
  • Maemura, Kosei1
  • Ishigami, Sumiya1
  • Natsugoe, Shoji1, 1
  • 1 Kagoshima University Graduate School of Medical and Dental Sciences, 35-1, Sakuragaoka 8 cho-me, Kagoshima City, Kagoshima, 890-8520, Japan , Kagoshima City (Japan)
Type
Published Article
Journal
Surgical Case Reports
Publisher
Springer Berlin Heidelberg
Publication Date
Jan 09, 2020
Volume
6
Issue
1
Identifiers
DOI: 10.1186/s40792-020-0776-5
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundPatients with esophagogastric junction cancer are increasing in Western and Eastern countries. Conversely, the clinical significance of surgical resection remains controversial in these patients. We report a long-term survivor of recurrent esophagogastric junction adenocarcinoma who underwent constructive multimodal therapy, including surgical resection.Case presentationA 51-year-old man underwent total gastrectomy for esophagogastric junction adenocarcinoma in 2009. In June 2010, computed tomography (CT) indicated a lung nodule and we partially resected the right lower lung. It was pathologically diagnosed as distant metastasis from esophagogastric junction cancer. After lung resection, he received adjuvant chemotherapy with S-1 for 1 year. In September 2014, CT demonstrated a swelling of the upper mediastinal lymph node with abnormal uptake on fluorine-18 fluorodeoxyglucose positron emission tomography. We performed an ultrasonography-guided needle biopsy, and he was diagnosed with lymph nodal recurrence of esophagogastric junction adenocarcinoma by pathological examination and was subsequently treated with capecitabine plus cisplatin plus trastuzumab. Since CT showed a reduction in the metastatic upper mediastinal lymph node after chemotherapy, he underwent upper mediastinal lymphadenectomy in April 2015. Following surgery, we provided radiation therapy to the upper mediastinum and chemotherapy with S-1. At the last report, the patient was alive for 8 years and 3 months since the first surgery.ConclusionsThis case report shows the clinical benefit of constructive multimodal therapy for recurrent esophagogastric junction adenocarcinoma.

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