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Long-term safety, efficacy, pharmacokinetics and pharmacodynamics of omalizumab in children with severe uncontrolled asthma.

Authors
  • Odajima, Hiroshi1
  • Ebisawa, Motohiro2
  • Nagakura, Toshikazu3
  • Fujisawa, Takao4
  • Akasawa, Akira5
  • Ito, Komei6
  • Doi, Satoru7
  • Yamaguchi, Koichi8
  • Katsunuma, Toshio9
  • Kurihara, Kazuyuki10
  • Teramoto, Takahide11
  • Sugai, Kazuko12
  • Nambu, Mitsuhiko13
  • Hoshioka, Akira14
  • Yoshihara, Shigemi15
  • Sato, Norio16
  • Seko, Noriko16
  • Nishima, Sankei17
  • 1 Department of Pediatrics, Fukuoka National Hospital, Fukuoka, Japan. Electronic address: [email protected] , (Japan)
  • 2 Department of Allergy, Clinical Research Center for Allergology and Rheumatology, Sagamihara National Hospital, Sagamihara, Japan. , (Japan)
  • 3 Yoga Allergy Clinic, Tokyo, Japan. , (Japan)
  • 4 Institute for Clinical Research, Mie National Hospital, Tsu, Japan. , (Japan)
  • 5 Division of Allergy, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan. , (Japan)
  • 6 Department of Allergy, Aichi Children's Health and Medical Center, Obu, Japan. , (Japan)
  • 7 Department of Pediatrics, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Habikino, Japan. , (Japan)
  • 8 Department of Pediatrics, The Fraternity Memorial Hospital, Tokyo, Japan. , (Japan)
  • 9 Department of Pediatrics, Jikei Daisan Hospital, Tokyo, Japan. , (Japan)
  • 10 Department of Allergy, Kanagawa Children's Medical Center, Yokohama, Japan. , (Japan)
  • 11 Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan. , (Japan)
  • 12 Department of Pediatrics, Fukuyama Medical Center, Fukuyama, Japan. , (Japan)
  • 13 Department of Pediatrics, Tenri Hospital, Tenri, Japan. , (Japan)
  • 14 Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Japan. , (Japan)
  • 15 Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan. , (Japan)
  • 16 Clinical Development, Novartis Pharma K.K., Tokyo, Japan. , (Japan)
  • 17 Department of Pediatrics, Fukuoka National Hospital, Fukuoka, Japan. , (Japan)
Type
Published Article
Journal
Allergology international : official journal of the Japanese Society of Allergology
Publication Date
Jan 01, 2017
Volume
66
Issue
1
Pages
106–115
Identifiers
DOI: 10.1016/j.alit.2016.06.004
PMID: 27507228
Source
Medline
Keywords
License
Unknown

Abstract

Long-term treatment with omalizumab is well-tolerated and effective in children with uncontrolled severe allergic asthma. No new safety findings were identified.

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