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Long-term Outcomes of Patients With Human Herpesvirus 6 Encephalitis

Authors
  • Fida, Madiha1
  • Hamdi, Ahmed M1
  • Bryson, Alexandra2
  • Razonable, Raymund R3
  • Abu Saleh, Omar1
  • 1 Division of Infectious Diseases, Virginia Commonwealth University Health System, Richmond, Virginia
  • 2 Department of Pathology, Virginia Commonwealth University Health System, Richmond, Virginia
  • 3 Division of Infectious Diseases and the William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, Minnesota
Type
Published Article
Journal
Open Forum Infectious Diseases
Publisher
Oxford University Press
Publication Date
Jun 05, 2019
Volume
6
Issue
7
Identifiers
DOI: 10.1093/ofid/ofz269
PMID: 31334297
PMCID: PMC6634437
Source
PubMed Central
Keywords
License
Unknown

Abstract

Human herpesviruses 6 (HHV-6) A and B cause encephalitis in patients with hematologic malignancies, especially those undergoing allogeneic hematopoietic stem cell transplantation. In this cohort of 10 patients, persistent neurologic deficits associated with moderate to severe bilateral hippocampal atrophy were characteristic long-term findings, despite prolonged antiviral treatment.

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