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A long-term evaluation of experimental potassium oxalate concentrations on dentin hypersensitivity reduction: A triple-blind randomized clinical trial.

Authors
  • Galvão, Alexia da Mata1
  • Zeola, Livia Fávaro2
  • Moura, Guilherme Faria3
  • Teixeira, Daniela Navarro Ribeiro4
  • Gonzaga, Ramon Corrêa de Queiroz5
  • da Silva, Gisele Rodrigues6
  • Soares, Paulo Vinícius7
  • 1 Department of Operative Dentistry and Dental Materials, School of Dentistry, Federal University of Uberlândia, Uberlândia, Minas Gerais, 38400-902, Brazil. Electronic address: [email protected] , (Brazil)
  • 2 Department of Operative Dentistry and Dental Materials, School of Dentistry, Federal University of Uberlândia, Uberlândia, Minas Gerais, 38400-902, Brazil. Electronic address: [email protected] , (Brazil)
  • 3 Department of Operative Dentistry and Dental Materials, School of Dentistry, Federal University of Uberlândia, Uberlândia, Minas Gerais, 38400-902, Brazil. Electronic address: [email protected] , (Brazil)
  • 4 Department of Operative Dentistry and Dental Materials, School of Dentistry, Federal University of Uberlândia, Uberlândia, Minas Gerais, 38400-902, Brazil. Electronic address: [email protected] , (Brazil)
  • 5 Department of Operative Dentistry and Dental Materials, School of Dentistry, Federal University of Uberlândia, Uberlândia, Minas Gerais, 38400-902, Brazil. Electronic address: [email protected] , (Brazil)
  • 6 Department of Operative Dentistry and Dental Materials, School of Dentistry, Federal University of Uberlândia, Uberlândia, Minas Gerais, 38400-902, Brazil. Electronic address: [email protected] , (Brazil)
  • 7 Department of Operative Dentistry and Dental Materials, School of Dentistry, Federal University of Uberlândia, Uberlândia, Minas Gerais, 38400-902, Brazil. Electronic address: [email protected] , (Brazil)
Type
Published Article
Journal
Journal of dentistry
Publication Date
Oct 01, 2019
Volume
89
Pages
103180–103180
Identifiers
DOI: 10.1016/j.jdent.2019.103180
PMID: 31415787
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The aim of this split-mouth, triple-blind, randomized clinical trial was to evaluate the long-term clinical efficacy of experimental potassium oxalate concentration (10%) in relieving dentin hypersensitivity (DH), after a four-session application protocol. Potassium oxalate gels with different concentrations (5 and 10%) were randomly assigned to half of the 31 patients from the sample in a split-mouth design. The desensitizers were applied following a four-session protocol, one session every 48 h. The primary outcome was the assessment of pain level with the visual analog scale (VAS, 0-10), at baseline, immediately after each desensitizing session, and also after the seventh day and along 1-,3-, 6-, 9- and 12-months follow-ups. Statistical analyses were performed using Friedman repeated measures and Wilcoxon signed rank tests (α = 0.05). For both groups, the minimum of three sessions were required for the achievement of lower DH levels. Regardless of the concentration, the desensitizing effect was maintained all the way to the end of the 6-month follow-up. The 10%-potassium oxalate group was more effective for both 9 and 12-months follow-up periods (p < 0.001). No complications and adverse effects were observed. When a four-session protocol is applied, both concentrations of potassium oxalate (5 and 10%) proved to be effective on DH reduction for up to six months. However, the higher concentration promoted better long-term results. The DH is an increasing condition in clinical practice, which affects the patient's life quality. This study provides primary clinical evidence, suggesting that multiple application sessions and higher concentrations of potassium oxalate may result in maintenance of the desensitizing effect for more extended periods. Trial registered under number: ClinicalTrials.gov NCT03083496. Copyright © 2019 Elsevier Ltd. All rights reserved.

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