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Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

Authors
  • Angelov, Angel
  • Bals, Robert
  • Bartholomäus, Alexander
  • Becker, Anke
  • Bezdan, Daniela
  • Bonifacio, Ezio
  • Bork, Peer
  • Clavel, Thomas
  • Colme-Tatche, Maria
  • Diefenbach, Andreas
  • Dilthey, Alexander
  • Fischer, Nicole
  • Förstner, Konrad
  • Frick, Julia-Stefanie
  • Gagneur, Julien
  • Goesmann, Alexander
  • Hain, Torsten
  • Hummel, Michael
  • Janssen, Stefan
  • Kalinowski, Jörn
  • And 47 more
Type
Published Article
Journal
Immunity
Publication Date
Nov 26, 2020
Volume
53
Issue
6
Pages
1296–1314
Identifiers
DOI: 10.1016/j.immuni.2020.11.017
PMID: 33296687
PMCID: PMC7689306
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

Bernardes et al. explore COVID-19 disease trajectories by performing longitudinal multi-omics analyses in peripheral blood samples from hospitalized patients. The analyses identify increased numbers of plasmablasts, interferon-activated megakaryocytes, and erythroid cells as hallmarks of severe disease and define molecular signatures linked to a fatal COVID-19 disease outcome.

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