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Longitudinal Epidemiological Study of Autism Subgroups Using Autism Treatment Evaluation Checklist (ATEC) Score.

Authors
  • Mahapatra, Shreyas1
  • Khokhlovich, Edward2
  • Martinez, Samantha1
  • Kannel, Benjamin2
  • Edelson, Stephen M3
  • Vyshedskiy, Andrey4, 5
  • 1 Boston University, Boston, USA.
  • 2 , Boston, MA, USA.
  • 3 Autism Research Institute, San Diego, CA, USA.
  • 4 Boston University, Boston, USA. [email protected]
  • 5 ImagiRation LLC, Boston, MA, USA. [email protected]
Type
Published Article
Journal
Journal of Autism and Developmental Disorders
Publisher
Springer-Verlag
Publication Date
May 01, 2020
Volume
50
Issue
5
Pages
1497–1508
Identifiers
DOI: 10.1007/s10803-018-3699-2
PMID: 30062397
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Here we report the results of the subgroup analyses of an observational cohort of children whose parents completed the Autism Treatment Evaluation Checklist (ATEC) over the period of several years. A linear mixed effects model was used to evaluate longitudinal changes in ATEC scores within different patient subgroups. All groups decreased their mean ATEC score over time indicating improvement of symptoms, however there were significant differences between the groups. Younger children improved more than the older children. Children with milder ASD improved more than children with more severe ASD in the Communication subscale. There was no difference in improvement between females vs. males. One surprising finding was that children from developed English-speaking countries improved less than children from non-English-speaking countries.

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