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Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf4.

Authors
Type
Published Article
Journal
Journal of gastroenterology
Publication Date
Volume
46
Issue
2
Pages
191–202
Identifiers
DOI: 10.1007/s00535-010-0346-x
PMID: 21125297
Source
Medline
License
Unknown

Abstract

Using mapping biopsy by DBE, we have demonstrated, for the first time, the molecular basis of the villus structure in the entire human small intestine in vivo. The present study showed that longitudinal cell formation was regulated by the colocalization of Hath1 and Klf4 that converted Paneth cell differentiation into goblet cell differentiation.

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