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Long-term survival of a patient with splenic angiosarcoma after resection, high-dose chemotherapy, and autologous peripheral blood stem cell transplantation.

Authors
  • Hara, Takeshi
  • Tsurumi, Hisashi
  • Kasahara, Senji
  • Ogawa, Kengo
  • Takada, Jun
  • Imai, Kenji
  • Takai, Koji
  • Kitagawa, Jun-ichi
  • Kiyama, Shigeru
  • Imai, Naoki
  • Oyama, Masami
  • Takami, Tsuyoshi
  • Moriwaki, Hisataka
Type
Published Article
Journal
Internal medicine (Tokyo, Japan)
Publication Date
Jan 01, 2010
Volume
49
Issue
20
Pages
2253–2257
Identifiers
PMID: 20962445
Source
Medline
License
Unknown

Abstract

A 48-year-old woman was admitted to our hospital in 2003, complaining of weight loss. Complete blood cell count revealed thrombocytopenia. Abdominal CT demonstrated marked splenomegaly. FDG-PET revealed a hot spot in the whole spleen. A splenectomy was performed. Histological examination was typical for angiosarcoma. Adjuvant chemotherapy was given, and high-dose chemotherapy with autologous peripheral blood stem cell transplantation was performed. Thrombocytopenia developed again in 2008. CT scan showed a hepatic tumor. A fine-needle biopsy of the liver revealed the first relapse. Despite hepatic lobectomy, radiofrequency ablations and administration of recombinant interleukin-2, she died from respiratory failure in 2009.

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