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Long-term overexpression of glucokinase in the liver of transgenic mice leads to insulin resistance.

Authors
  • Ferre, T
  • Riu, E
  • Franckhauser, S
  • Agudo, J
  • Bosch, F
Type
Published Article
Journal
Diabetologia
Publication Date
Dec 01, 2003
Volume
46
Issue
12
Pages
1662–1668
Identifiers
PMID: 14614559
Source
Medline
License
Unknown

Abstract

Long-term overexpression of glucokinase increases hepatic lipogenesis and circulating lipids, which lead to insulin resistance. Our results also suggest that the liver plays a key role in the onset of diabetes.

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