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Long-term observations of two siblings with Lafora disease treated with zonisamide.

Authors
  • Yoshimura, I
  • Kaneko, S
  • Yoshimura, N
  • Murakami, T
Type
Published Article
Journal
Epilepsy Research
Publisher
Elsevier
Publication Date
Sep 01, 2001
Volume
46
Issue
3
Pages
283–287
Identifiers
PMID: 11518630
Source
Medline
License
Unknown

Abstract

We have reported long-term clinical follow-up for two siblings with Lafora disease, a brother and sister, one of whom autopsied. Both siblings had repeated attacks of severe myoclonus, tonic and tonic-clonic convulsions, and intractable status epilepticus. The addition of orally administered zonisamide brought about striking effective seizure control for about 12-14 years in both patients, relieving not only myoclonus and generalized tonic-clonic seizures but also intractable status epilepticus.

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