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Long-term immunogenicity of hepatitis B vaccination in children and adolescents in a southern Italian town

Authors
  • Stroffolini, T.1
  • Guadagnino, V.2
  • Caroleo, B.2
  • De Sarro, G.2
  • Focà, A.3
  • Liberto, M. C.3
  • Giancotti, A.3
  • Barreca, G. S.3
  • Marascio, N.3
  • Lombardo, F. L.4
  • Staltari, O.2
  • 1 Policlinico Umberto I, Department of Infectious and Tropical Diseases, Institute of Tropical Diseases, Viale del Policlinico 155, Rome, 00161, Italy , Rome (Italy)
  • 2 University “Magna Graecia” of Catanzaro, Department of Experimental and Clinical Medicine, Viale Europa, Loc. Germaneto, Catanzaro, 88100, Italy , Catanzaro (Italy)
  • 3 University “Magna Graecia” of Catanzaro, Department of Medical Sciences, Viale Europa, Loc. Germaneto, Catanzaro, 88100, Italy , Catanzaro (Italy)
  • 4 National Institute of Health, Viale Regina Elena 299, Rome, 00161, Italy , Rome (Italy)
Type
Published Article
Journal
Infection
Publisher
Springer-Verlag
Publication Date
Dec 16, 2011
Volume
40
Issue
3
Pages
299–302
Identifiers
DOI: 10.1007/s15010-011-0233-2
Source
Springer Nature
Keywords
License
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Abstract

PurposeUniversal anti-hepatitis B vaccination of infants and of 12-year-old children became mandatory in Italy in 1991. The purpose of this study was to evaluate the persistence of anti-hepatitis B surface (HBs) antibodies several years after a primary course of vaccination.MethodsIn 2010, anti-HBs titers were measured in all subjects aged between 5 and 25 years residing in a southern Italian town. Individuals with an anti-hepatitis B antibody concentration of 10 IU/ml or more were considered to be protected.ResultsOf the 671 subjects evaluated, 149 (30%) lacked protective antibodies. Fifty-three (29.4%) of the subjects had been vaccinated ≤10 years earlier and 96 (30.3%) more than 10 years earlier (P = not significant). Subjects vaccinated in infancy were more likely to lack protective anti-HBs antibodies than subjects vaccinated at 12 years of age, regardless of the years elapsed since immunization.ConclusionsMost subjects maintained protective antibodies for a considerable number of years after vaccination. Vaccination in adolescence results in more prolonged immunogenicity than vaccination in infancy.

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