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Long non-coding RNAs in hematopoietic regulation.

Authors
  • Li, Weiqian1, 2
  • Ren, Yue1, 2
  • Si, Yanmin1, 2
  • Wang, Fang1, 2
  • Yu, Jia1, 2
  • 1 State Key Laboratory of Medical Molecular Biology, Department of Biochemistry & Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College (PUMC), Beijing, 100005, China. , (China)
  • 2 Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences, Beijing, 100730, China. , (China)
Type
Published Article
Journal
Cell regeneration (London, England)
Publication Date
Dec 01, 2018
Volume
7
Issue
2
Pages
27–32
Identifiers
DOI: 10.1016/j.cr.2018.08.001
PMID: 30671227
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Long non-coding RNAs (lncRNAs) have crucial roles via tethering with DNA, RNA or protein in diverse biological processes. These lncRNA-mediated interactions enhance gene regulatory networks and modulate a wide range of downstream genes. It has been demonstrated that several lncRNAs act as key regulators in hematopoiesis. This review highlights the roles of lncRNAs in normal hematopoietic development and discusses how lncRNA dysregulation correlates with disease prognoses and phenotypes.

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