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Long noncoding RNAs in development and cancer: potential biomarkers and therapeutic targets

Authors
  • Fatima, Roshan1
  • Akhade, Vijay Suresh1
  • Pal, Debosree1
  • Rao, Satyanarayana MR1
  • 1 Molecular Biology and Genetics Unit, Jawaharlal Nehru Center for Advanced Scientific Research, Jakkur, Bangalore, 560064, India , Jakkur (India)
Type
Published Article
Journal
Molecular and Cellular Therapies
Publisher
"ClinTransMed, AB"
Publication Date
Jun 12, 2015
Volume
3
Issue
1
Identifiers
DOI: 10.1186/s40591-015-0042-6
Source
Springer Nature
Keywords
License
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Abstract

Long noncoding RNAs are emerging as key players in various fundamental biological processes. We highlight the varied molecular mechanisms by which lncRNAs modulate gene expression in diverse cellular contexts and their role in early mammalian development in this review. Furthermore, it is being increasingly recognized that altered expression of lncRNAs is specifically associated with tumorigenesis, tumor progression and metastasis. We discuss various lncRNAs implicated in different cancer types with a focus on their clinical applications as potential biomarkers and therapeutic targets in the pathology of diverse cancers.

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