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Long Non-coding RNA NEAT1 as an Emerging Biomarker in Breast and Gynecologic Cancers: a Systematic Overview.

Authors
  • Thankachan, Sanu1
  • Bhardwaj, Boddapati Kalyani1
  • Venkatesh, Thejaswini2
  • Suresh, Padmanaban S3
  • 1 School of Biotechnology, National Institute of Technology, Calicut, Kerala, 673601, India. , (India)
  • 2 Department of Biochemistry and Molecular Biology, Central University of Kerala, Kasargod, Kerala, 671316, India. , (India)
  • 3 School of Biotechnology, National Institute of Technology, Calicut, Kerala, 673601, India. [email protected] , (India)
Type
Published Article
Journal
Reproductive Sciences
Publisher
SAGE Publications
Publication Date
Sep 01, 2021
Volume
28
Issue
9
Pages
2436–2447
Identifiers
DOI: 10.1007/s43032-021-00481-x
PMID: 33569749
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Long non-coding RNAs (lncRNAs) are emerging regulators of cellular pathways, especially in cancer development. Among the lncRNAs, nuclear paraspeckle assembly transcript 1 (NEAT1) forms a scaffold for a nuclear body; the paraspeckle and aberrant expression of NEAT1 have been reported in breast and gynecologic cancers (ovarian, cervical, endometrial, and vulvar). Abundantly expressed NEAT1 in breast and gynecologic cancers generally contribute to tumor development by sponging its corresponding tumor-suppressive microRNAs or interacting with various regulatory proteins. The distinct expression of NEAT1 and its contribution to tumorigenic pathways make it a promising therapeutic target in breast and gynecologic cancers. Herein, we summarize the functions and molecular mechanisms of NEAT1 in human breast, ovarian, cervical, endometrial, and vulvar cancers. Furthermore, we emphasize its critical role in the formation of paraspeckle development and its functions. Conclusively, NEAT1 is a considerable biomarker with a bright prospect and can be therapeutically targeted to manage breast and gynecologic cancers. © 2021. Society for Reproductive Investigation.

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