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Long noncoding RNA H19 - a new player in the pathogenesis of liver diseases.

Authors
  • Yang, Zhihong1
  • Zhang, Ting2
  • Han, Sen2
  • Kusumanchi, Praveen2
  • Huda, Nazmul2
  • Jiang, Yanchao2
  • Liangpunsakul, Suthat3
  • 1 Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address: [email protected] , (India)
  • 2 Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana. , (India)
  • 3 Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Roudebush Veterans Administration Medical Center, Indianapolis, Indiana; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana. , (India)
Type
Published Article
Journal
Translational research : the journal of laboratory and clinical medicine
Publication Date
Apr 01, 2021
Volume
230
Pages
139–150
Identifiers
DOI: 10.1016/j.trsl.2020.11.010
PMID: 33227504
Source
Medline
Language
English
License
Unknown

Abstract

The liver is a vital organ that controls glucose and lipid metabolism, hormone regulation, and bile secretion. Liver injury can occur from various insults such as viruses, metabolic diseases, and alcohol, which lead to acute and chronic liver diseases. Recent studies have demonstrated the implications of long noncoding RNAs (lncRNAs) in the pathogenesis of liver diseases. These newly discovered lncRNAs have various functions attributing to many cellular biological processes via distinct and diverse mechanisms. LncRNA H19, one of the first lncRNAs being identified, is highly expressed in fetal liver but not in adult normal liver. Its expression, however, is increased in liver diseases with various etiologies. In this review, we focused on the roles of H19 in the pathogenesis of liver diseases. This comprehensive review is aimed to provide useful perspectives and translational applications of H19 as a potential therapeutic target of liver diseases. Copyright © 2020 Elsevier Inc. All rights reserved.

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