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Long non-coding RNA LINC00987 may function as a tumor suppressor in lung adenocarcinoma

Authors
Type
Published Article
Journal
F1000Research
Publisher
"F1000 Research, Ltd."
Publication Date
May 24, 2018
Volume
7
Identifiers
DOI: 10.12688/f1000research.14785.1
Source
MyScienceWork
License
Green

Abstract

Long non-coding RNAs (lncRNAs) are a group of transcripts over 200 nucleotides in length that do not code for proteins. The association of the dysregulation of numerous lncRNAs with several malignancies, including lung cancer, has been frequently reported. This study aims to inspect the association of genomic and transcriptomic alterations to the lncRNA LINC00987 with lung adenocarcinoma, a subtype of lung cancer, using a bioinformatic approach. To this end, we used three publically available online databases, cBioPortal, the International Cancer Genome Consortium Data Portal and the GEPIA web server. In short, our results demonstrated that LINC00987 expression might have a tumor suppressive role in lung adenocarcinoma and levels of expression could be of prognostic value for this cancer type.

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