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Long-acting local anesthetics attenuate FMLP-induced acute lung injury in rats.

Authors
  • Schley, Marcus T
  • Casutt, Matthias
  • Haberthür, Christoph
  • Dusch, Martin
  • Rukwied, Roman
  • Schmelz, Martin
  • Schmeck, Joachim
  • Schüpfer, Guido K
  • Konrad, Christoph J
Type
Published Article
Journal
Anesthesia & Analgesia
Publisher
Ovid Technologies (Wolters Kluwer) - Anesthesia & Analgesia
Publication Date
Sep 01, 2009
Volume
109
Issue
3
Pages
880–885
Identifiers
DOI: 10.1213/ane.0b013e3181ae5ef1
PMID: 19690261
Source
Medline
License
Unknown

Abstract

Bupivacaine and ropivacaine attenuated N-formyl-L-leucine-methionyl-L-phenylalanine-induced PAP, reduced lung edema, and diminished ET-1 release. Lidocaine and mepivacaine are more effective in reducing PAP and edema formation, but long-acting local anesthetics also inhibit ET-1 depletion and therefore have increased anti-inflammatory properties.

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